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Why Some Golden Retrievers Seem Anxious — New Study Points to Shared Genes

A University of Cambridge study published in PNAS analyzed DNA from about 1,300 golden retrievers and matched genetic data to owner-reported behavior. Researchers identified 18 candidate genes linked to traits such as trainability, stranger fear, and aggression; 12 of these have human equivalents associated with emotion or cognition. Examples include PTPN1, ROMO1, and ASCC3, which correlated with aggressiveness, sensitivity-related trainability, and fearfulness respectively. The findings suggest shared genetic roots for some behaviors in dogs and humans and underscore that genetics, environment, and training together shape a dog's temperament.

Why Some Golden Retrievers Seem Anxious — New Study Points to Shared Genes

Many dog owners know that breed gives you a head start on temperament, but individual dogs still vary widely. Golden retrievers are famed for their friendly, eager-to-please nature, yet some display persistent fear, anxiety, or aggression. A recent study in Proceedings of the National Academy of Sciences (PNAS) links several such behaviors in golden retrievers to specific genes — some of which have counterparts associated with emotions and cognition in humans.

The study and what it found

Researchers at the University of Cambridge analyzed DNA from about 1,300 golden retrievers and matched genetic profiles with detailed owner-reported behavior questionnaires. Because single breeds tend to be genetically more uniform than mixed populations, the team could more easily connect genetic variants to behavioral traits. They identified 18 candidate genes associated with traits such as trainability, fear of strangers, and aggression; 12 of those genes have human equivalents already linked to emotional or cognitive traits.

Notable gene links

  • PTPN1: In humans this gene is associated with intelligence and major depression; in the study it correlated with higher aggressiveness in some dogs.
  • ROMO1: Tied in people to cognitive performance and to traits like irritability and sensitivity; in golden retrievers it related to measures of trainability and responsiveness.
  • ASCC3: Connected in humans to neuroticism and anxiety and linked here to fearfulness in dogs.

As co-author and veterinary geneticist Dr. Eleanor Raffan noted, 'The findings are striking — they provide strong evidence that humans and golden retrievers share genetic roots for some aspects of behavior.' Co-author Anna Morros-Nuevo added that understanding these biological influences can help owners respond with more empathy when dogs show anxious or fearful behaviors.

Why this matters

These genetic links help explain why some dogs develop behavioral patterns that resemble human psychiatric conditions, such as compulsive behaviors reminiscent of obsessive-compulsive disorder, and why older dogs may show Alzheimer’s-like cognitive decline. Importantly, genetics is only one part of the picture: environment, training, early socialization, and veterinary care also shape behavior and can mitigate risk.

If your golden trembles at the doorbell or avoids strangers, consider that a genetic predisposition may be at work. Pairing compassion with appropriate training, counter-conditioning, and, when needed, veterinary or behavioral specialist support gives anxious dogs the best chance to improve.

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