Kyushu University researchers discovered that trisulfide compounds—especially lipoic acid trisulfide (LASSS)—can protect and modify hepatocyte growth factor (HGF), creating a more robust “Super HGF” that resists nitration and binds the c-Met receptor more effectively. Early lab tests showed both LASSS and glutathione trisulfide (GSSSG) reduced HGF nitration. While the discovery points to a potential way to slow age-related muscle loss and aid recovery after prolonged inactivity, human trials are still required.
Japanese Team Identifies 'Super HGF' Compound That May Slow Age-Related Muscle Loss
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Researchers at Kyushu University in Fukuoka, Japan, report a promising laboratory finding that could help slow age-related muscle loss. Led by Professor Ryuichi Tatsumi from the Faculty of Agriculture, the team found that certain trisulfide compounds appear to protect and modify hepatocyte growth factor (HGF), producing a strengthened form the researchers call “Super HGF.”
What the Researchers Did
The group tested two sulfur-containing trisulfide antioxidants—glutathione trisulfide (GSSSG) and lipoic acid trisulfide (LASSS)—for their effect on HGF, a protein that activates muscle repair and regeneration. In early laboratory experiments, both compounds suppressed chemical modification (nitration) of HGF, while untreated HGF became more vulnerable to nitration-related dysfunction over time.
Key Findings
According to the researchers, LASSS not only neutralized reactive molecules but may also interact directly with HGF to induce a subtle structural change, producing an enhanced form that binds the c-Met receptor more strongly and resists nitration.
The team described the result as unexpectedly pronounced: simply mixing HGF with LASSS produced what they call an enhanced “Super HGF” with increased resilience against chemical damage.
Potential Implications and Caution
These findings suggest a possible strategy to slow sarcopenia (age-related muscle loss) and to help recovery after prolonged inactivity, such as extended bed rest. The researchers also note potential applications for companion animals like cats and dogs to preserve mobility and quality of life.
Important caveat: Results so far are from initial laboratory studies. More preclinical work and human clinical trials are necessary to confirm safety, optimal dosing, and real-world effectiveness before this approach can be considered a treatment.
Reported July 24 via Science Daily and Kyushu University communications. Research led by Ryuichi Tatsumi; findings are preliminary.
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